Mr. S.P. Dunuweera

Mr. S.P. Dunuweera |Clyto Access

University of Peradeniya, Peradeniya20400, SRI LANKA

Speaker

Expertise: Nanoscience and Nanotechnology

Biography:

S.P. Dunuweera has completed his B.Sc. Special Degree in Chemistry last year from University of Peradeniya and currently working as a Demonstrator in Chemistry at the same University. He is following an M.Sc. Degree in Nanoscience and Nanotechnology and holds CHRM, PQHRM ,GCP.Psycholog, LIPs degrees. He has published over 20 papers and communications at the inception of his academic career. He has participated and presented in 15 National and International Conferences.

Presentation:

Title: Targeted Delivery of Cisplatin

Abstract:

Cisplatin is a commonly used anticancer drug which is the first generation of platinum-based anticancer drugs developed. The cis configuration enables the binding of the coordination complex to one or two DNA strand(s) and thereby crosslinking the DNA strands triggering the cells to die in a programmed manner. Cisplatin is administered to patients intravenously as a short-term infusion in normal saline for chemotheraputic treatment to solid malignancies. It is used to treat various types of cancers which include sarcomas and some carcinomas such as small cell lung cancer, ovarian cancer, lymphomas, bladder cancer, cervical cancer, and germ cell tumours. It is found that cisplatin is particularly effective against testicular cancer with a cure rate of 10-85%. When administered into blood, cisplatin reacts with thiol containing proteins present in blood plasma thus reducing its bioavailability and increasing cytotoxicity. Cisplatin is associated with numerous side effects which include nephrotoxicity, nurotoxicity, nausea and vomiting, ototoxicity (hearing loss), electrolyte disturbance and haemolytic anemia. In order to increase the bioavailability and to reduce dosage and cytotoxic effects to healthy cells, we have encapsulated cisplatin in hollow nanoparticles of the vaterite form of calcium carbonate and studied the release kinetics of the drug in solutions at different pH values. We developed a facile method for the synthesis of hollow spherical vaterite polymorph of calcium carbonate nanoparticles using precipitation reaction of NaHCO3 with Ca(CH3COO)2 in H2O/EG media. Cisplatin was successfully encapulated together with folic acid in these hollow nanoparticles and 86% encapsulation efficiency of the drug is achived. Folic acid targets the drug to cancerous cells through folate-folic acid interactions and slightly low pH conditions prevailing in cancer cells helps slow and steady release of the drug only at the vicinity of the cancer cells. Slightly basic or neutral pH conditions prevailing in blood and healthy cells prevents the release of drug and hence minimizing cytotoxicity to healthy cells. The encapsulation for slow release results in decreased dosage and cytotoxicity of the drug while increasing the efficacy and the bio-availability of the drug to destroy only cancer cells without harming healthy cells.

Related Conferences :

2nd world summit on Nanotechnology and Nanomedicine Research