Mr. Pubudu Premarathne

Mr. Pubudu Premarathne |Clyto Access

University of Peradeniya, Sri Lanka

Poster Presentation

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Title: Mathematical modelling of Microemulsion basednovel drug delivery system for Diclofenac sodium with synthesized glycolipid as permeation enhancer

Abstract:

Mathematical models related to the drug release provides detailed description on chemical processes and mass transpiration govern in drug delivery systems as well as the effect of design parameters, such as the device geometry and drug loading, on drug release mechanism with a few experimental studies. In last decades, there were large numbers of researches on controlled release formulations, to enhance the drug effectiveness and decrease the administration periods in treatments with minimal side effect to the patient. This modelling provides important physical parameters such as steady state flux, drug diffusion coefficient regarding the experimental data. It provides detailed description of drug release kinetics as well as this is the ideal tool to understand the comprehension phenomena of releasing process and bring the acceptable and optimized formulation in to market. There are number of theoretical and semi empirical models, which illustrate the overall releasing kinetics of drug. Depending on the qualitative and quantitative changes of the formulation, drug release may be altered. Under thin investigation the releasing process was studied with Zero order model, First-order model, Higuch square root time model, Korsmeyer-Peppas model and Weibull model. In this investigation, optimized ME systems were prepared using Olive oil, water and the non-ionic lipophilic surfactant Sorbitan monooleate (Span 80) by selecting suitable compositions of both W/O (water in oil) and O/W (Oil in Water) emulsion systems from the phase diagram constructed at 70 ºC . Then, Diclofenac sodium (1.00 % w/w) was introduced to the selected W/O and O/W emulsions separately as well as together and in vitro release of both drugs through a pig ear (ear epidermis) fitted to a Franz diffusion cell system was observed with and without glycolipid (hexadecyl-β-D-glucopyranoside) (0.05% (w/w)) as permeation enhancer. Aqueous solution of DS (1% (w/w)) was used as the control. The optimized ME formulations model drug show higher permeability (Kp) and higher amount of release of 76.35% and 63.52% for W/O and O/W respectively. The kinetics of the release process of DS, can be identified as first order kinetics obeying the Higuchi model of drug release. Release process can be further concluded as a one dimensional diffusion model with Higuchi model and release process was considered to follow diffusion controlled release.

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