Dr. P. G. Kumarasamy

Dr. P. G. Kumarasamy |Clyto Access

Bioinformatics Centre, ARIS Cell

Speaker

Expertise:

Biography: Dr. Peria Gounder Kumarasamy is currently working as Professor and Head, Bioinformatics Center & ARIS Cell, Madras Veterinary College, Chennai and associated with several external funded research schemes in the area of Bioinformatics, Agriculture information system and establishment of genomic laboratory for fecundity genes in TANUVAS. He graduated (B.V.Sc.) from Madras Veterinary College, Chennai during 1989 where he also completed his M.V.Sc. in Animal Genetics and Breeding in 1992 and Ph.D. in Gene mapping in buffalo during 2001 securing first class in all the programs. He pursued his post doctoral fellowship training in Buffalo Genomics at Center for Cellular and Molecular Biology, Hyderabad for one year through the prestigious DBT Postdoc Fellowship. He got his Senior Research Fellowship in both, Indian Council for Agriculture Research (ICAR) and Council of Scientific and Industrial Research (CSIR), Govt. of India for his PG Program. At present he is concentrating on drug designing using bioinformatics tools and molecular docking of anticancer substance available in Indian Herbs used in traditional medicine in India.

Presentation:

Title: Bioinformatics approaches in cancer therapy: A medical revolution

Abstract: Cancer bioinformatics is one of the multiple ways to concentrate bioinformatics methods in cancer. There is a need to develop cancer bioinformatics-specific methodologies or introduce new and advanced bioinformatics tools to answer the specific question of cancer.  Cancer bioinformatics plays an important role in monitoring and predicting the efficiency and effectiveness of the precision medicine. Cancer bioinformatics and systems biology are expected to improve prevention, diagnosis and treatment through therapy design. An in-silicoapproach was undertaken to find the best lead compound from the medicinal plants to combat lung cancer which is the most frequent cause of death in human beings within the cancer etiology. The effects caused by Chemotheraphy, paves way to identify new targets for the development of drugs from plant sources using computational tools. The 3-D structure of the four targeted proteins viz, Cytochrome C Oxidase Copper Chaperone (COX17), Aspartate Carbamoyltransferase (ATCs), Epidermal Growth Factor Receptor (EGFR) and Galectin-3 were retrieved. Thirty Plant anti-cancerous bioactive compounds  from the plants commonly available in Tamil Nadu were selected from the documentary sources  were also  retrieved. Among these compounds,  Curcumin from turmeric and  Glucoside  from  aloe verashowed the highest dock score  73.005 and 80.697 respectively  against the target protein COX17,  ATCs and EGFR. Pharmacokinetics (PK) and Pharmacodynamics (PD) of the two lead compounds were studied. The dock score, PK and PD properties were compared between Curcumin and Glucoside where the latter is the best compound when compared to the first, which could be analysed for the potency in in-vivo and in-vitro mechanism for the development of new drug to treat Lung Cancer.

Related Conferences :

International Conference on Cancer Care and Cure