Dr. Gerardo F. Goya

 Dr. Gerardo F. Goya |Clyto Access

University of Zaragoza, Spain

Keynote Speaker

Expertise: Nanoscale and Nanomedicine

Biography:

Dr. Gerardo F. Goya is an associate professor at the University of Zaragoza, Spain. He has been Associate Professor at the University of Sao Paulo (Brazil) and he is currently a researcher at the Institute of Nanoscience of Aragón (INA), University of Zaragoza. Prof. Goya’s pioneering team (http://www.unizar.es/gfgoya) on magnetic hyperthermia in Spain established that induced cell death with magnetic hyperthermia without temperature rise is possible. His team has developed engineered MNPs for neural guidance under externally applied magnetic fields. He has over 130 publications on nanomagnetism and bioapplications and holds two patents. Prof. Goya has lead the design, development, and building of devices for measuring power absorption for magnetic hyperthermia, which made the basis for a spin-off company, nB Nanoscale Biomagnetics, of which he is co-founder and scientific advisor.

Presentation:

Title: Magnetic hyperthermia in nanomedicine: New applications of magnetic nanoparticles as heaters.

Abstract:

Magnetic hyperthermia (MHT) has started its application as standalone therapy few years ago. The clinical use of MHT requires that tolerable effects on patients must be reached by using the minimum concentration of the heating agent. The treatment of deep, inaccessible human tumors by MHT is based on the transparency of human tissues/organs to the ultralow frequencies (100-500 kHz) of the radiation used. This property allows to increase only the local tumour temperature up to apoptotic levels (if previously loaded with magnetic nanoparticles), with minimal side effects on the surrounding healthy tissue. Therefore the design of highly efficient magnetic nanoparticles (MNPs) as power absorbers and heating agents within the intracellular environment is crucial. Since MHT generates heat at the intracellular space, a key question prosed many years ago was whether intracellular heat release could imply local apoptotic mechanisms that could be more efficient than exogenous heating (EHT). We have addressed this question by systematic comparison of MHT and EHT experiments with the same conditions and target temperatures. Numerical simulation of the response under magnetic fields the best magnetic parameters (e.g., magnetic anisotropy, magnetization, dipolar interactions, etc.) using a numerical model of the particle-field interactions allows to optimize the heating efficiency at the intracellular environment. The output of this protocol is the largest in vitro specific power absorption (SPA) values reported so far. These results pave the way for the magnetism-based design of MNPs that can retain their heating efficiency in vivo, thereby improving the outcome of clinical hyperthermia experiments. To this aim, human neuroblastoma SH-SY5Y cells were co-cultivated with magnetic nanoparticles (MNPs) and exposed to both external heat source and alternating magnetic field (AMF), in the form of dense pellets to mimic the micro-tumor environment. The effect of both heating sources was studied following the cell viability at the same target temperatures. We found that MHT was able to induce a decrement in cell viability that is larger than the corresponding EHT for the same target temperatures. In terms of temperature efficiency, MHT requires an average temperature that is 6°C lower than that required with EHT to produce a similar cytotoxic effect. In addition to the biological effects, the analysis from electron microscopy images of the cells after the EHT and MHT treatments showed morphological evidences of a higher level of cell damage when MHT was applied. These differences were associated to the intracellular action of the magnetic nanoparticles, triggered by the local release of heat by the external magnetic fields.

Related Conferences :

2nd world summit on Nanotechnology and Nanomedicine Research